Publications

Tissue Memory Relies on Stem Cell Priming in Distal Undamaged Areas

20 April 2023

Epithelial cells that participated in wound repair elicit a more efficient response to future …...

DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells

23 January 2023

The correct establishment of DNA methylation patterns during mouse early development is essential …...

3plex enables deep computational investigation of triplex forming lncRNAs

2023

Long non-coding RNAs (lncRNAs) regulate gene expression through different molecular mechanisms, …...

Single-Cell Sequencing for Everybody

07 December 2021

Over the past 7 years, single-cell sequencing has become very popular. For this reason, many …...

Flow Cytometry for Beginners: Hints and Tips for Approaching the Very First Single-Cell Technique

2021

While many single-cell proteomics techniques have been rapidly developed over the past decade, flow …...

Hair follicle stem cell progeny heal blisters while pausing skin development

4 June 2021

Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it …...

Long Noncoding RNAs in Human Stemness and Differentiation

March 01, 2021

Embryonic differentiation at the gastrulation stage is a very tightly regulated process in …...

The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development

18 May 2021

SMYD3 (SET and MYND domain containing protein 3) is a methylase over-expressed in cancer cells and …...

Mapping Rora expression in resting and activated CD4+ T cells

2021

The transcription factor Rora has been shown to be important for the development of ILC2 and the …...

Gene expression variability across cells and species shapes innate immunity

24 October 2018

As the first line of defence against pathogens, cells mount an innate immune response, which varies …...

Locked and Loaded: Inflammation Training Prepares Skin Epithelial Stem Cells for Trauma

7 December 2017

Memory of a trauma and how to cope with it is useful for acting rapidly in the event of a second …...

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

2016

Background Differentiation of lymphocytes is frequently accompanied by cell cycle changes, …...

T cell fate and clonality inference from single-cell transcriptomes

2016

We developed TraCeR, a computational method to reconstruct full-length, paired T cell receptor (TCR) …...

Flow Cytometry for Beginners: Hints and Tips for Approaching the Very First Single-Cell Technique

12 November 2021

While many single-cell proteomics techniques have been rapidly developed over the past decade, flow …...

Single‐cell technologies are revolutionizing the approach to rare cells

2015

In the last lustrum single-cell techniques such as single-cell quantitative PCR, RNA and DNA …...

Single‐cell technologies to study the immune system

2015

The immune system is composed of a variety of cells that act in a coordinated fashion to protect the …...

Computational assignment of cell-cycle stage from single-cell transcriptome data

2015

The transcriptome of single cells can reveal important information about cellular states and …...

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

2015

Recent technical developments have enabled the transcriptomes of hundreds of cells to be assayed in …...

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis

2014

T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and …...

Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

It has long been recognized that the hair follicle growth cycle and oscillation in the thickness of …...

Accounting for technical noise in single-cell RNA-seq experiments

2013

Single-cell RNA-seq can yield valuable insights about the variability within a population of …...

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

2013

Elucidating the epigenetic mechanisms underlying muscle mass determination and skeletal muscle …...

TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration

2010

How regeneration cues are converted into the epige- netic information that controls gene expression …...