Research

Dissecting Vulvodynia at High Resolution

Our lab is dedicated to uncovering the molecular mechanisms that regulate gene expression in various female diseases.

Since 2023, we have applied our expertise to the study of vulvodynia, a frequently overlooked women's health condition that affects approximately 1 in 7 women over the course of their lives. Using transcriptomic analyses, we aim to identify novel diagnostic markers. In parallel, we are investigating deregulated molecular pathways to pave the way for new therapeutic strategies. We are particularly interested in the transcriptional regulation by transcription factors, which crucially control cell differentiation and plasticity.

Studying Extramammary Paget Disease of the Vulva

Extramammary Paget's Disease (EMPD) is a rare adenocarcinoma that accounts for approximately 1-2% of vulvar malignancies and predominantly affects postmenopausal women. EMPD is characterized by a high rate of recurrence, even following surgical intervention, which remains the standard treatment. Our research focuses on elucidating the molecular underpinnings of EMPD through transcriptome profiling and high-resolution omics approaches, with the goal of identifying key genetic and molecular drivers of the disease. This work aims to improve diagnostic precision, anticipate recurrence, and support the development of targeted therapies.

Impact of Vulvodynia on Women's Lives

Vulvodynia can significantly impair not only woman's sexual life but also everyday activities like sitting, wearing tight clothing, sports, and even walking. Diagnosis is challenging as it's a "diagnosis of exclusion," made when other diseases are ruled out. Despite its prevalence, vulvodynia is often overlooked due to the lack of specific markers. For these reasons we are conducting transcriptomic analyses on patients to identify specific disease biomarkers to ease the diagnosis of this multifactorial disease.

Empowering Women's Health Research

Research fundings

In 2022, in order to secure funding for this research project, we collaborated with the "Comitato Vulvodinia e Neuropatia del Pudendo," to organize a crowdfunding campaign called "doppiaVproject." This campaign successfully raised over 20,000 euros. Furthermore, we have recently received funding from the Ministry of Research (MUR) and from the Fondazione CRT (Cassa di Risparmio di Torino) to further pursue our objectives (PRIN 2022).

Join us on a journey to understand and combat vulvodynia, a debilitating condition affecting countless women worldwide. Through transcriptomic analyses, we aim to uncover specific biomarkers, revolutionizing diagnosis and treatment approaches.

See our publications